The mean dose of oral vitamin for the first (preoperative) group was 5 mg and for the over-anticoagulated group it was 10 mg. There was a strong correlation between the actual and predicted change in the INR. ![]() The clinical manifestations and diagnosis of anticoagulant rodenticide poisoning and an overview of rodenticide poisonings other than anticoagulant rodenticides is provided separately. Patients whose INR was >5.0 held their dose of warfarin and received a dose of vitamin K 1 that was predicted (from the formula) to lower their INR into the targeted therapeutic range. This topic reviews the management of anticoagulant rodenticide (also called long-acting anticoagulant rodenticide LAAR) poisoning. Patients who required reversal of their INR prior to minor surgery or a dental procedure took vitamin K 1 36 h before the procedure and continued their daily dose of warfarin: the aim was to reduce their INR to between 1.5 and 2.0. Oral vitamin K 1 was administered as a scored 5 mg tablet. In a prospective cohort study, they assessed the validity of a regression formula to predict the correct dose of vitamin K 1 in two groups of patients: (1) those who required reversal of their anticoagulant therapy because they required minor surgery and (2) those whose INR was >5.0 and who were not bleeding. In this issue of CHEST (see page 1546), Wentzien and colleagues investigated a novel approach to lowering the INR in anticoagulated patients.
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